TY  - JOUR
PY  - 2024//
TI  - Sleep disturbances and incident risk of major depressive disorder in a population-based cohort
JO  - Psychiatry research
A1  - Solelhac, Geoffroy
A1  - Imler, Théo
A1  - Strippoli, Marie-Pierre F.
A1  - Marchi, Nicola Andrea
A1  - Berger, Mathieu
A1  - Haba-Rubio, José
A1  - Raffray, Tifenn
A1  - Bayon, Virginie
A1  - Lombardi, Anne Sophie
A1  - Ranjbar, Setareh
A1  - Siclari, Francesca
A1  - Vollenweider, Peter
A1  - Marques-Vidal, Pedro
A1  - Geoffroy, Pierre-Alexis
A1  - Leger, Damien
A1  - Stephan, Aurélie
A1  - Preisig, Martin
A1  - Heinzer, Raphael
SP  - e115934
EP  - e115934
VL  - 338
IS  - 
N2  - Sleep disturbances are well-known symptoms of major depressive disorder (MDD). However, the prospective risk of MDD in the presence of sleep disturbances in a general population-based cohort is not well known. This study investigated associations between both polysomnography (PSG)-based or subjective sleep features and incident MDD. Participants representative of the general population who had never had MDD completed sleep questionnaires (n = 2000) and/or underwent PSG (n = 717). Over 8 years' follow-up, participants completed psychiatric interviews enabling the diagnosis of MDD. Survival Cox models were used to analyze associations between sleep features and MDD incidence. A higher Epworth Sleepiness Scale and presence of insomnia symptoms were significantly associated with a higher incidence of MDD (hazard ratio [HR] [95 % confidence interval (CI)]: 1.062 [1.022-1.103], p = 0.002 and 1.437 [1.064-1.940], p = 0.018, respectively). Higher density of rapid eye movements in rapid eye movement (REM) sleep was associated with a higher incidence of MDD in men (HR 1.270 [95 % CI 1.064-1.516], p = 0.008). In women, higher delta power spectral density was associated with a lower MDD incidence (HR 0.674 [95 % CI 0.463-0.981], p = 0.039). This study confirmed the associations between subjective and objective sleep features and the incidence of MDD in a large community dwelling cohort.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2024.115934
ID  - ref1
ER  -