TY  - JOUR
PY  - 2021//
TI  - Case Report: Buprenorphine-A Treatment for Psychological Pain and Suicidal Ideation?
JO  - American journal on addictions
A1  - Benhamou, Ori-Michael
A1  - Lynch, Sean
A1  - Klepacz, Lidia
SP  - 80
EP  - 82
VL  - 30
IS  - 1
N2  - BACKGROUND AND OBJECTIVES: Buprenorphine is commonly used to manage opioid use disorder; however, the literature describes its potential role in treating treatment-resistant depression.  METHODS: We present a patient with bipolar disorder and opioid use disorder, who presented status post-suicide attempt.  RESULTS: After initiating buprenorphine-naloxone, the patient reported rapid improvement in depressive symptoms, pain, and suicidal ideation.  DISCUSSION AND CONCLUSIONS: This case demonstrates buprenorphine's antisuicidal and mood-stabilizing capabilities, potentially via antagonizing κ-opioid receptors as well as reinstating the balance between reward and antireward circuitry.  SCIENTIFIC SIGNIFICANCE: This case highlights buprenorphine-naloxone as a treatment for both treatment-resistant depression and opioid use disorder, as well as buprenorphine's rapid antidepressant, analgesic, and antisuicidal effects. (Am J Addict 2021;30:80-82).<p /> <p>Language: en</p>
LA  - en
SN  - 1055-0496
UR  - http://dx.doi.org/10.1111/ajad.13063
ID  - ref1
ER  -