TY  - JOUR
PY  - 2022//
TI  - Mental health among patients with non-Hodgkin lymphoma: A Danish nationwide study of psychotropic drug use in 8750 patients and 43 750 matched comparators
JO  - American journal of hematology
A1  - Øvlisen, Andreas Kiesbye
A1  - Jakobsen, Lasse Hjort
A1  - Kragholm, Kristian Hay
A1  - Nielsen, René Ernst
A1  - de Nully Brown, Peter
A1  - Dahl-Sørensen, Rasmus Bo
A1  - Frederiksen, Henrik
A1  - Mannering, Nikolaj
A1  - Josefsson, Pär Lars
A1  - Ludvigsen Al-Mashhadi, Ahmed
A1  - Jørgensen, Judit Mészáros
A1  - Dessau-Arp, Andriette
A1  - Clausen, Michael Roost
A1  - Pedersen, Robert Schou
A1  - Torp-Pedersen, Christian
A1  - Severinsen, Marianne Tang
A1  - El-Galaly, Tarec Christoffer
SP  - 749
EP  - 761
VL  - 97
IS  - 6
N2  - Psychological distress following cancer diagnosis may lead to mental health complications including depression and anxiety. Non-Hodgkin lymphomas (NHLs) include indolent and aggressive subtypes for which treatment and prognosis differ widely. Incident use of psychotropic drugs (PDs-antidepressants, antipsychotics, and anxiolytics) and its correlation to lymphoma types can give insights into the psychological distress these patients endure. In this prospective matched cohort study, we used nationwide population-based registries to investigate the cumulative risk of PD use in NHL patients compared to a sex- and age-matched cohort from the Danish background population. In addition, contact patterns to psychiatric departments and incident intentional self-harm or completed suicide were explored. In total, 8750 NHL patients and 43 750 matched comparators were included (median age 68; male:female ratio 1.6). Median follow-up was 7.1 years. Two-year cumulative risk of PD use was higher in NHL patients (16.4%) as compared to the matched comparators (5.1%, p < .01); patients with aggressive NHL subtypes had the highest incidence. Prescription rates were higher in the first years after diagnosis but approached the rate of the matched population 5 years into survivorship in aggressive NHLs, whereas patients with indolent subtypes continued to be at higher risk. NHL patients had a slightly higher two-year risk of suicide/intentional self-harm (0.3%) as compared to the matched comparators (0.2%, p = .01). These results demonstrate that mental health complications among NHL patients are frequent. Routine assessment for symptoms of depression and anxiety should be consider as part of standard follow-up of NHL patients.<p /> <p>Language: en</p>
LA  - en
SN  - 0361-8609
UR  - http://dx.doi.org/10.1002/ajh.26538
ID  - ref1
ER  -