TY  - JOUR
PY  - 2021//
TI  - Early Life Stress and Chronobiological Rhythms Desynchronization: Possible Impact on Mood Symptoms and Suicidal Ideation in Bipolar Disorder
JO  - Journal of nervous and mental disease
A1  - Caruso, Danila
A1  - Palagini, Laura
A1  - Miniati, Mario
A1  - Massa, Lucia
A1  - Marazziti, Donatella
A1  - Geoffroy, Pierre Alexis
A1  - Etain, Bruno
SP  - 518
EP  - 524
VL  - 209
IS  - 7
N2  - The study aimed at investigating the potential impact of early stressful events on the clinical manifestations of bipolar disorder (BD). A sample of 162 adult individuals with BD was assessed using the Structural Clinical Interview for DSM-5, the Beck Depression Inventory-II, the Young Mania Rating Scale, the Early Trauma Inventory Self Report-Short Form, the Biological Rhythms Interview of Assessment in Neuropsychiatry, the Insomnia Severity Index, and the Scale for Suicide Ideation. A significant path coefficient indicated a direct effect of early life stressors on biological rhythms (coeff. = 0.26; p < 0.001) and of biological rhythms on depressive symptoms (coeff. = 0.5; p < 0.001), suicidal risk (coeff. = 0.3; p < 0.001), and insomnia (coeff. = 0.34; p < 0.001). Data suggested that the desynchronization of chronobiological rhythms might be one mediator of the association between early life stress and the severity of mood symptoms/suicidal ideation in BD. Addressing circadian rhythm alterations in subjects exposed to early stressors would help in preventing consequences of those stressors on BD.<p /> <p>Language: en</p>
LA  - en
SN  - 0022-3018
UR  - http://dx.doi.org/10.1097/NMD.0000000000001333
ID  - ref1
ER  -