TY  - JOUR
PY  - 2021//
TI  - Prevalence and predictors of treatment-resistant schizophrenia in a tertiary hospital in Northeast Brazil
JO  - Trends in psychiatry and psychotherapy
A1  - Soares, Douglas de Sousa
A1  - Carvalho, Danyelle Rolim
A1  - Ribeiro, Mellanie Dellylah Trinta
A1  - Diniz, Elton Jorge Bessa
A1  - Rêgo, Alcides Ferreira
SP  - 270
EP  - 277
VL  - 43
IS  - 4
N2  - OBJECTIVE: To investigate epidemiological factors related to treatment-resistant schizophrenia (TRS) in Northeast Brazil, a region where data about mental health are still scarce.  METHODS: This retrospective cross-sectional study included all patients with schizophrenia currently receiving treatment at the outpatient psychiatric clinic of a tertiary hospital in Northeast Brazil. They were divided into TRS and treatment-responsive groups, and epidemiological characteristics of both groups were compared. A logistic regression model investigated factors related to treatment resistance.  RESULTS: Two hundred and five patients were included, 155 treatment-resistant and 50 treatment-responsive. The TRS group had higher use of benzodiazepines (36.1 vs. 18%, p = 0.017) and antiepileptics (36.8 vs. 8.0%, p < 0.001), antipsychotic polypharmacy (28.6 vs. 8%, p = 0.003) and suicide attempts (35.6 vs. 20%, p = 0.04). Age at onset was younger (19.7±7.3 vs. 24.6±8.6 years, p = 0.001) and CGI was higher in TRS (3.72±1.00 vs. 3.16±1.00, p = 0.001). In logistic regression, being married was a protector (odds ratio [OR] = 0.248, 95% confidence interval [95%CI] 0.091-0.679, p = 0.007) and younger age at onset was a predictor (OR = 1.076, 95%CI 1.034-1.120, p < 0.001) of treatment resistance.  CONCLUSION: Early onset of disease was associated with more treatment resistance, while being married with less resistance. Clinicians should identify early predictors of resistance in order to reduce unfavorable outcomes.<p /> <p>Language: en</p>
LA  - en
SN  - 2237-6089
UR  - http://dx.doi.org/10.47626/2237-6089-2020-0151
ID  - ref1
ER  -