TY  - JOUR
PY  - 2021//
TI  - Six-week oral ketamine treatment for chronic suicidality is associated with increased grey matter volume
JO  - Psychiatry research. Neuroimaging
A1  - Gallay, Cyrana C.
A1  - Forsyth, Grace
A1  - Can, Adem T.
A1  - Dutton, Megan
A1  - Jamieson, Daniel
A1  - Jensen, Emma
A1  - Hermens, Daniel F.
A1  - Bennett, Maxwell R.
A1  - Lagopoulos, Jim
SP  - e111369
EP  - e111369
VL  - 317
IS  - 
N2  - Chronic suicidality has been associated with neuronal atrophy in cortico-striato-limbic regions and is thought to be mediated via a glutamatergic imbalance. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been posited to exert anti-suicidal effects by promoting neurogenesis via modulation of glutamatergic transmission. This voxel-based morphometry study examined the effect of ketamine on whole brain grey matter in adults with chronic suicidality. Grey matter in the periaqueductal grey, nucleus accumbens, putamen, caudate, and thalamus was significantly increased following 6 weeks of low dose oral ketamine treatment. These results support the notion that ketamine rapidly enhances synaptic plasticity within striato-limbic regions.<p /> <p>Language: en</p>
LA  - en
SN  - 0925-4927
UR  - http://dx.doi.org/10.1016/j.pscychresns.2021.111369
ID  - ref1
ER  -