TY  - JOUR
PY  - 2021//
TI  - Clinical characteristics of bipolar disorders with postpartum depressive onset
JO  - Progress in neuro-psychopharmacology and biological psychiatry
A1  - Tebeka, Sarah
A1  - Godin, Ophelia
A1  - Mazer, Nicolas
A1  - Bellivier, Frank
A1  - Courtet, Philippe
A1  - Etain, Bruno
A1  - Gard, Sebastien
A1  - Leboyer, Marion
A1  - Llorca, Pierre-Michel
A1  - Loftus, Josephine
A1  - Olié, Emilie
A1  - Passerieux, Christine
A1  - Polosan, Mircea
A1  - Schwan, Raymund
A1  - Belzeaux, Raoul
A1  - Dubertret, Caroline
A1  - FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators, 
SP  - e110225
EP  - e110225
VL  - 107
IS  - 
N2  - BACKGROUND: Postpartum period is associated with an increased risk of bipolar disorder diagnosis and relapse, mainly major depressive episode. Onset during this period might be associated with specific characteristics.  AIM: To compare the socio-demographic and clinical characteristics of parous women presenting with bipolar disorder and an index depressive episode occurring during or outside the postpartum period.  METHODS: Using the multicenter cohort FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorders), we considered all women who started their BD with a major depressive episode and have at least one child. We compared two groups depending on the onset: in or outside the postpartum period.  RESULTS: Among the 759 women who started BD with a major depressive episode, 93 (12.2%) had a postpartum onset, and 666 (87.8%) had not. Women who started BD in the postpartum period with a major depressive episode have a more stable family life, more children, an older age at onset, more Bipolar 2 disorder, less history of suicide attempts, less depressive episodes and more mood stabilizer treatments as compared to those who started with a major depressive episode outside the postpartum period. The multivariable logistic regression showed that women with an onset in the postpartum period had significantly more children, less lifetime depressive episodes and a lower rate of history of suicide attempts as compared to women with an onset outside the postpartum period.  DISCUSSION: Our results suggest that women starting their BD with postpartum depression have a more favorable course of BD, especially less history of suicide attempt and less lifetime depressive episodes.<p /> <p>Language: en</p>
LA  - en
SN  - 0278-5846
UR  - http://dx.doi.org/10.1016/j.pnpbp.2020.110225
ID  - ref1
ER  -