TY  - JOUR
PY  - 2020//
TI  - Frontolimbic brain volume abnormalities in bipolar disorder with suicide attempts
JO  - Psychiatry research
A1  - Jabbi, Mbemba
A1  - Weber, Wade
A1  - Welge, Jeffrey
A1  - Nery, Fabiano
A1  - Tallman, Maxwell
A1  - Gable, Austin
A1  - Fleck, David E.
A1  - Lippard, Elizabeth T. C.
A1  - DelBello, Melissa
A1  - Adler, Caleb
A1  - Strakowski, Stephen M.
SP  - e113516
EP  - e113516
VL  - 294
IS  - 
N2  - Over 2.3 million people in the United States live with bipolar disorder. Sixty percent of those with a bipolar disorder diagnosis attempt suicide at least once in their lifetime and up to 19% die by suicide. However, the neurobiology of suicide attempts in bipolar disorder remains unclear. We studied the gray matter volume (GMV) of 81 participants with a bipolar-I diagnosis (age-range: 14-34 years old) and 40 healthy participants (age-range 14.7-32 years old) to compare their neuroanatomy and histories of suicide attempt. In the bipolar group, 42 were manic with ages ranging from 14-30.6 years, and 39 were depressed with ages ranging from 14-34.3 years). Twenty three bipolar participants had a suicide attempt history, and 58 had no suicide attempt history. All participants completed behavioral/diagnostic assessments and MRI. We focused on a predefined frontolimbic circuitry in bipolar disorder versus controls to first identify diagnostic GMV correlates and to specifically identify GMV correlates for suicide attempt history. We found reduced GMV in bipolar diagnosis versus controls in the subgenual cingulate and dorsolateral prefrontal cortices. Our observed regional GMV reductions were associated with histories of suicide attempts and measures of individual variations in current suicidal ideation at the time of scanning.<p /> <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2020.113516
ID  - ref1
ER  -