TY  - JOUR
PY  - 2020//
TI  - Bilateral thalamic changes in anti-NMDAR encephalitis presenting with hemichorea and dystonia and acute transient psychotic disorder
JO  - Journal of neuroimmunology
A1  - Dubey, Souvik
A1  - Ghosh, Ritwik
A1  - Dubey, Mahua Jana
A1  - Sengupta, Samya
A1  - Benito-León, Julián
A1  - Ray, Biman Kanti
SP  - e577329
EP  - e577329
VL  - 347
IS  - 
N2  - Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is one of the most common causes of autoimmune encephalitis. Both movement disorders and neuropsychiatric manifestations are considered core features of anti-NMDAR encephalitis. Strong clinical suspicion, along with NMDAR antibody positivity in paired sample of serum and cerebrospinal fluid, with supportive MRI changes clinch diagnosis in majority. We herein report a case of a middle-aged woman with subacute behavioral abnormalities, which were so severe that forced her to attempt suicide. Hemichorea and dystonia, which appeared later in course, are not previously reported movement disorders in combination in anti-NMDAR encephalitis. Further, magnetic resonance imaging showed bilateral thalamic hyperintensities with diffusion restriction, which are in turn not described in this entity. After amalgamation of history, especially the presence of neuropsychiatric symptoms, clinical features, physical examination, and investigations, the diagnosis of anti-NMDAR encephalitis could be established. Our case not only highlights that the combination of hemichorea and dystonia can be features of anti-NMDAR encephalitis, but adds novelty by bilateral symmetric thalamic changes.<p /> <p>Language: en</p>
LA  - en
SN  - 0165-5728
UR  - http://dx.doi.org/10.1016/j.jneuroim.2020.577329
ID  - ref1
ER  -