TY  - JOUR
PY  - 1996//
TI  - Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case
JO  - Arquivos de Neuro-Psiquiatria
A1  - Oliveira, Acary Souza Bulle
A1  - Calia, Leandro Cortoni
A1  - Kiyomoto, Beatriz Hitomi
A1  - Póvoa, Eliane Focaccia
A1  - Schmidt, Beny
A1  - Gabbai, Alberto Alain
SP  - 288
EP  - 92
VL  - 54
IS  - 2
N2  - A 21 year old male ingested podophyllin in a suicide attempt. The disorder was marked by seizures, coma, peripheral neuropathy, renal failure and acute necrotizing myopathy, an unusual finding. The coma and systemic disturbance resolved within theree weeks. The myopathy resolved in 7 weeks, demonstrating a high capacity of muscle recuperation. The sensorimotor peripheral neuropathy persisted until the patient's death 9 weeks after the ingestion, due to septicemia. This report confirms the transient central neurotoxicity of podophyllin and persistent peripheral neurotoxicity of podophyllin, and describes a reversible necrotizing myopathy associated to mitochondrial abnormalities, a sitill unreported feature of podophillin toxicity.<p /> <p>Language: en</p>
LA  - en
SN  - 0004-282X
UR  - http://dx.doi.org/
ID  - ref1
ER  -