TY  - JOUR
PY  - 1992//
TI  - Naloxone as an antidote for benzodiazepine: an experimental and clinical study
JO  - Egyptian journal of psychiatry
A1  - Sanaa S., Salem
A1  - Ibrahim A., Ramadan
SP  - 53
EP  - 65
VL  - 15
IS  - 1
N2  - This study evaluates the potential antidote action of naloxone on experimentally induced diazepam and flunitrazepam [benzodiazepines] intoxication in dogs. Its antidote effects is also evaluated in a clinical sample of 8 patients suffering from flunitrazepam intoxication. The clinical findings were suggestive of an antagonistic action of naloxone in flunitrazepam intoxication. It was also found that flunitrazepam exhibits a different pharmacological profile from other members of the benzodiazepine group. Our findings of a selective naloxane-flunitrazepam reversal need to be explained in relation to the mechanism of action of this benzodiazepine, as well as to the equated naloxane-opiates reversal<p /> <p>Language: en</p>
LA  - en
SN  - 0254-136X
UR  - http://dx.doi.org/
ID  - ref1
ER  -