TY - JOUR PY - 1992// TI - Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor JO - Angewandte Chemie (International ed. in English) A1 - Vessières, A. A1 - Top, S. A1 - Vaillant, C. A1 - Osella, D. A1 - Mornon, J.‐p. A1 - Jaouen, G. SP - 753 EP - 755 VL - 31 IS - 6 N2 - Derivatizing biomolecules with transition‐metal fragments can be a useful approach to some biochemical problems, for example in labeling hormone receptors. The estradiol derivatives 1-4 deactivate the estradiol receptor to varying degrees, allowing conclusions to be drawn concerning the chemical environment of the binding site. (Figure Presented.) Copyright © 1992 by VCH Verlagsgesellschaft mbH, Germany
Language: en
LA - en SN - 1433-7851 UR - http://dx.doi.org/10.1002/anie.199207531 ID - ref1 ER -