TY  - JOUR
PY  - 1992//
TI  - Inhibitors of GDP-mannose dehydrogenase of Pseudomonas aeruginosa mucoid strains
JO  - European journal of medicinal chemistry
A1  - Elloumi, N.
A1  - Moreau, B.
A1  - Aguiar, L.
A1  - Jaziri, N.
A1  - Sauvage, M.
A1  - Hulen, C.
A1  - Capmau, M.
SP  - 149
EP  - 154
VL  - 27
IS  - 2
N2  - The synthesis of 5′-amino-5′-deoxy guanosine was improved in order to use it for elaboration of liposolubles GDP-mannose analogues. GDP-mannose is the substrate of GDP-mannose dehydrogenase, a key enzyme in the alginates biosynthetic pathway of Pseudomonas aeruginosa mucoid strains. Guanosine, 5′-amino-5′-deoxy-guanosine, 5′-(3-hydroxypropyl)-amino-5′-deoxy-guanosine and 2 GDP mannose analogues were tested on the GDP mannose dehydrogenase activity. The more potent inhibitor was the GDP-mannose analogue where mannose is substituted by a 6-ethynyl derivative, linked to an N2-acetyl-2′,3′-O-isopropylidene guanosine by a sulfonyl amino carbonyl arm. As a hypothesis, this compound could be a suicide or irreversible inhibitor for the enzyme. © 1992.<p /> <p>Language: en</p>
LA  - en
SN  - 0223-5234
UR  - http://dx.doi.org/10.1016/0223-5234(92)90103-8
ID  - ref1
ER  -