TY  - JOUR
PY  - 1993//
TI  - Cytochromes P450 from Papilio polyxenes: Adaptations to host plant allelochemicals
JO  - Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
A1  - Zumwalt, J.G.
A1  - Neal, J.J.
SP  - 111
EP  - 118
VL  - 106
IS  - 1
N2  - 1. Papilio polyxenes, a caterpillar which feeds on xanthotoxin-containing plants, has cytochromes P450 that are six- to 100-fold less sensitive to the suicide substrate inhibitor, xanthotoxin, than cytochromes P450 from Manduca sexta, which does not survive on xanthotoxin-containing plants. 2. Xanthotoxin is a suicide substrate inhibitor of O-demethylation of p-nitroanisole by M. sexta microsomes but a reversible inhibitor of O-demethylation by P. polyxenes microsomes. 3. Aldrin epoxidation is irreversibly inhibited by xanthotoxin in both species. 4. Patterns of cross inhibition demonstrate that O-demethylase and aldrin epoxidase from both species and the P. polyxenes xanthotoxin-metabolizing cytochrome P450 are distinct enzymes. © 1993.<p /> <p>Language: en</p>
LA  - en
SN  - 0742-8413
UR  - http://dx.doi.org/10.1016/0742-8413(93)90261-I
ID  - ref1
ER  -