TY  - JOUR
PY  - 1996//
TI  - Acute dystonia caused by tetrabenazine - What does it tell us about pathophysiology?
JO  - European journal of neurology
A1  - Dietrichs, E.
A1  - Magnusson, A.
A1  - Opjordsmoen, S.
SP  - 395
EP  - 396
VL  - 3
IS  - 4
N2  - A 21-year-old woman with Gilles de la Tourette syndrome developed acute dystonia 24 h after ingesting 750 mg of tetrabenazine in a suicide attempt. The symptoms were rapidly resolved on diazepam and orphenadrine administration. Acute dystonia caused by tetrabenazine is extremely rare, but may help us understand the pathophysiology of drug-induced dystonic reactions. We suggest that acute dystonia in this patient was caused by catecholamine depletion and a subsequently reduced dopaminergic neurotransmission rather than by dopamine receptor blockade.<p /> <p>Language: en</p>
LA  - en
SN  - 1351-5101
UR  - http://dx.doi.org/10.1111/j.1468-1331.1996.tb00236.x
ID  - ref1
ER  -