TY  - JOUR
PY  - 1992//
TI  - Use of granulocyte colony-stimulating factor in the treatment of pancytopenia secondary to colchicine overdose
JO  - Annals of pharmacotherapy
A1  - Katz, R.
A1  - Chuang, L. C.
A1  - Sutton, J. D.
SP  - 1087
EP  - 1088
VL  - 26
IS  - 9
N2  - OBJECTIVE: To report a case of pancytopenia following colchicine overdose and to discuss the use of granulocyte colony-stimulating factor (G-CSF) for treating this severe complication.  CASE SUMMARY: A 19-year-old man developed pancytopenia four days after ingestion of approximately 50-60 0.6-mg colchicine tablets in a suicide attempt. His pancytopenia resolved after subcutaneous administration of one 300-micrograms dose of G-CSF. The patient recovered from his other multiorgan disturbances during his hospitalization and was discharged from the hospital with elevated liver enzyme concentrations.  CONCLUSIONS: Colchicine overdose is rare, but can be fatal. The use of G-CSF appears to be beneficial in alleviating bone marrow depression in colchicine overdose situations.<p /> <p>Language: en</p>
LA  - en
SN  - 1060-0280
UR  - http://dx.doi.org/10.1177/106002809202600907
ID  - ref1
ER  -