TY  - JOUR
PY  - 1993//
TI  - Clozapine cases with fatal, toxic or therapeutic concentrations
JO  - International journal of legal medicine
A1  - Worm, K.
A1  - Kringsholm, B.
A1  - Steentoft, A.
SP  - 115
EP  - 118
VL  - 106
IS  - 3
N2  - The neuroleptic drug clozapine is used in the treatment of schizophrenia and is characterized by not having the extrapyramidal side-effects usually shown by neuroleptics. Unfortunately clozapine has other side-effects, which limit its use. This study presents methods for the analysis of clozapine and desmethylclozapine in whole blood and tissue. Case histories and pathology findings are described for 3 autopsy cases with fatal concentrations of clozapine, 5 with toxic concentrations and 2 with therapeutic concentrations together with the concentrations found in a living person.<p /> <p>Language: en</p>
LA  - en
SN  - 0937-9827
UR  - http://dx.doi.org/10.1007/BF01225229
ID  - ref1
ER  -