TY  - JOUR
PY  - 1994//
TI  - Estimated glucose requirement following massive insulin overdose in a patient with type 1 diabetes
JO  - Diabetic medicine
A1  - Fasching, P.
A1  - Roden, M.
A1  - Stühlinger, H. G.
A1  - Kurzemann, S.
A1  - Zeiner, A.
A1  - Waldhäusl, W.
A1  - Laggner, A. N.
SP  - 323
EP  - 325
VL  - 11
IS  - 3
N2  - A well-documented case of a 35-year-old male Type 1 diabetic patient who was admitted as an emergency after having injected 1500 international units (IU) of insulin (750 IU regular insulin,750 IU NPH-insulin) subcutaneously as a suicidal attempt is reported. Computing disappearance rates of glucose from its infused amounts necessary to maintain euglycaemia during 65 h after the insulin injection in analogy to experimental hyperinsulinaemic euglycaemic clamp examinations, a glucose consumption of 55.6 mumol kg-1 min-1 was found at peak serum insulin concentrations of about 14,400 pmol l-1. The insulin-induced glucose dynamics resemble closely those seen in healthy persons and Type 1 diabetic subjects during a 10 mU kg-1 min-1 euglycaemic clamp. This information may be useful in the handling of similar cases of insulin intoxication.<p /> <p>Language: en</p>
LA  - en
SN  - 0742-3071
UR  - http://dx.doi.org/10.1111/j.1464-5491.1994.tb00279.x
ID  - ref1
ER  -