TY - JOUR PY - 1994// TI - Determination of methaqualone and its metabolites in urine and blood by UV, GC/FID and GC/MS JO - Yao xue xue bao A1 - Liu, F. A1 - Liu, Y. T. A1 - Feng, C. L. A1 - Luo, Y. SP - 610 EP - 616 VL - 29 IS - 8 N2 - A systematic procedure for the determination of methaqualone and its metabolites in blood and urine by UV spectrophotometry, GC and GC/MS was developed. Urine and blood samples were from a suicidal patient who ingested 18 tablets of methaqualone. Both solid phase and liquid-liquid extractions were used in the extraction and clean-up of the samples. The total amount of methaqualone and its metabolites was measured by UV spectrophotometry. The amount of parent methaqualone was quantitated by GC/FID. Methaqualone and its 10 metabolites including two acetyl metabolites were found in urine and blood. This procedure is useful for monitoring drugs in emergency treatment.

Language: en

LA - en SN - 0513-4870 UR - http://dx.doi.org/ ID - ref1 ER -