TY  - JOUR
PY  - 1995//
TI  - [A case of paracetamol retard poisoning with fatal outcome]
JO  - Ugeskrift for Laeger
A1  - Lystbaek, B. B.
A1  - Nørregaard, P.
SP  - 899
EP  - 900
VL  - 157
IS  - 7
N2  - A case of fatal paracetamol (acetaminophen) poisoning in a 26-year-old woman who developed liver necrosis is described. The patient reported having ingested 11 g of a slow-release paracetamol preparation and a certain amount of alcohol and benzodiazepine. An unknown dose of phenobarbital (phenemal) had been ingested 24 hours previously, leading to a serum phenobarbital concentration of 0.195 mmol/l at the time of admission. The patient was initially treated with N-acetylcysteine intravenously. This treatment was discontinued after five hours due to a serum paracetamol concentration of 0.49 mmol/l, well below the "treatment line" paracetamol concentration of 0.8 mmol/l six hours after ingestion. Possible aggravating factors are discussed, including sustained high serum concentration of paracetamol due to the slow-release preparation and enzyme induction caused from concomitant phenobarbital and alcohol intake, as well as benzodiazepines displacing paracetamol from liver enzymes. These factors make serum paracetamol concentrations undependable; the importance of continuing N-acetylcysteine treatment in spite of "safe" serum concentrations in the above cases is stressed.<p /> <p>Language: da</p>
LA  - da
SN  - 0041-5782
UR  - http://dx.doi.org/
ID  - ref1
ER  -