TY  - JOUR
PY  - 1990//
TI  - Gas chromatographic determination of cresols in the biological fluids of a non-fatal case of cresol intoxication
JO  - Forensic science international
A1  - Yashiki, M.
A1  - Kojima, T.
A1  - Miyazaki, T.
A1  - Chikasue, F.
A1  - Ohtani, M.
SP  - 21
EP  - 29
VL  - 47
IS  - 1
N2  - A simple and rapid method for analysis of free and conjugated cresols in biological fluids was developed. Prior to and following freeing of the conjugated cresols by acid hydrolysis in a sealed ampoule, free cresols were extracted by Extrelut column extraction, determined by gas chromatography, and confirmed by gas chromatography-mass spectrometry. In a non-fatal case of cresol intoxication a 46-year-old male had ingested about 100 ml of a saponated cresol soap solution. The concentrations of xylenol (2,4- and/or 2,5-dimethylphenol) and p- and m-cresol in the serum sample collected on admission were 15.8 micrograms/g, 43.3 micrograms/g and 73.8 micrograms/g, respectively. The total cresol concentration of 117 micrograms/g in the serum is within the range of fatal concentrations, and it is suspected therefore that the patient's recovery was due to adequate therapy alone.<p /> <p>Language: en</p>
LA  - en
SN  - 0379-0738
UR  - http://dx.doi.org/10.1016/0379-0738(90)90282-4
ID  - ref1
ER  -