TY  - JOUR
PY  - 1991//
TI  - 3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin
JO  - Canadian journal of neurological sciences
A1  - Ludolph, A. C.
A1  - He, F.
A1  - Spencer, P. S.
A1  - Hammerstad, J.
A1  - Sabri, M.
SP  - 492
EP  - 498
VL  - 18
IS  - 4
N2  - 3-Nitropropionic acid (3-NPA)--a suicide inhibitor of succinate dehydrogenase--is a widely distributed plant and fungal neurotoxin known to induce a damage to basal ganglia, hippocampus, spinal tracts and peripheral nerves in animals. Recent reports from Northern China indicate that 3-NPA is also likely to be responsible for the development of putaminal necrosis with delayed dystonia in children after ingestion of mildewed sugar cane. This article discusses the role of 3-NPA in the causation of the disease in China, its neurotoxic effects in animals and the potential role for this compound as a probe of selective neuronal vulnerability.<p /> <p>Language: en</p>
LA  - en
SN  - 0317-1671
UR  - http://dx.doi.org/10.1017/s0317167100032212
ID  - ref1
ER  -