TY  - JOUR
PY  - 1996//
TI  - Acute necrotizing myopathy and podophyllin toxicity. Report of a fatal case
JO  - Arquivos de Neuro-Psiquiatria
A1  - Oliveira, A. S.
A1  - Calia, L. C.
A1  - Kiyomoto, B. H.
A1  - Póvoa, E. F.
A1  - Schmidt, B.
A1  - Gabbai, A. A.
SP  - 288
EP  - 292
VL  - 54
IS  - 2
N2  - A 21 year old male ingested podophyllin in a suicide attempt. The disorder was marked by seizures, coma, peripheral neuropathy, renal failure and acute necrotizing myopathy, an unusual finding. The coma and systemic disturbances resolved within three weeks. The myopathy resolved in 7 weeks, demonstrating a high capacity of muscle recuperation. The sensorimotor peripheral neuropathy persisted until the patient's death 9 weeks after the ingestion, due to septicemia. This report confirms the transient central neurotoxicity of podophyllin and persistent peripheral neurotoxicity of podophyllin, and describes a reversible necrotizing myopathy associated to mitochondrial abnormalities, a still unreported feature of podophyllin toxicity.<p /> <p>Language: en</p>
LA  - en
SN  - 0004-282X
UR  - http://dx.doi.org/10.1590/s0004-282x1996000200017
ID  - ref1
ER  -