TY  - JOUR
PY  - 1998//
TI  - Acute renal failure after massive ingestion of gliclazide in a suicide attempt
JO  - Renal failure
A1  - Barracca, A.
A1  - Ledda, O.
A1  - Michittu, B.
A1  - Pili, G. F.
A1  - Manca, O.
A1  - Pani, A.
A1  - Altieri, P.
SP  - 533
EP  - 537
VL  - 20
IS  - 3
N2  - Gliclazide, a sulfonlyurea class molecule, is used to control glycaemic levels in non-insulin-dependent diabetes mellitus. Acute and chronic toxicity studies, conducted in various animal species, have demonstrated a very low toxicity. We report a patient who developed acute renal failure due to acute tubular necrosis following a massive ingestion of gliclazide in an suicide attempt. The patient ingested 28 grams of gliclazide; the normal dose of gliclazide is 80 mg one or twice a day. At admission the patient was hypoglycaemia and in a few days became oliguric with an increase in the serum creatinine concentration, but with a normal blood urea nitrogen level. He underwent dialysis and ten days after ingestion of gliclazide, his renal function improved rapidly.<p /> <p>Language: en</p>
LA  - en
SN  - 0886-022X
UR  - http://dx.doi.org/10.3109/08860229809045142
ID  - ref1
ER  -