TY  - JOUR
PY  - 1998//
TI  - Evaluation of endozepine-like immunoreactivity in the frontal cortex of suicide victims
JO  - Neuroreport
A1  - Rochet, T.
A1  - Tonon, M. C.
A1  - Kopp, N.
A1  - Vaudry, H.
A1  - Miachon, S.
SP  - 53
EP  - 56
VL  - 9
IS  - 1
N2  - Diazepam-binding inhibitor (DBI) and its processing products, including the octadecaneuropeptide (ODN), are polypeptides called endozepines which have multiple biological effects, including regulation of mitochondrial steroidogenesis and modulation of GABA-gated chloride channels. Concentrations of ODN-like immunoreactivity (ODN-Li) were measured by radioimmunoassay in the frontal cortex of nine drug-free suicides and nine drug-free sudden-death victims. The level of ODN-Li was higher in the right than in the left frontal cortex, in both suicide (p < 0.05) and control (p < 0.02) subjects. No significant differences were found between suicides and controls either in the right and left cortex, or when considering the gender and the post-mortem diagnosis of depression.<p /> <p>Language: en</p>
LA  - en
SN  - 0959-4965
UR  - http://dx.doi.org/10.1097/00001756-199801050-00011
ID  - ref1
ER  -