TY  - JOUR
PY  - 1999//
TI  - Non-fatal clozapine (LEPONEX) intoxication with toxicokinetic evaluation
JO  - Veterinary and human toxicology
A1  - Bédry, R.
A1  - Deschamps, L.
A1  - Pehourcq, F.
A1  - Moore, N.
A1  - Pillet, O.
A1  - Favarel-Garrigues, J. C.
SP  - 20
EP  - 22
VL  - 41
IS  - 1
N2  - A 29-y-old male attempted suicide with 3000 mg clozapine, 150 mg zopiclone, alprazolam and unknown quantities of alcohol. He was admitted in a deep hypotonic coma with respiratory depression, inhalation pneumonia and vascular collapse. Symptomatic treatment involved mechanical ventilation, vascular filling and antibiotics. The patient was discharged from the Intensive Care Unit 72 h after the suicide attempt with no sequelae. To detect and quantify clozapine in plasma, high-pressure liquid chromatography showed a 4 h absorption phase and a peak serum concentration of 5200 ng/ml. Three successive elimination t1/2 values of 38, 24 and 13 h were calculated.<p /> <p>Language: en</p>
LA  - en
SN  - 0145-6296
UR  - http://dx.doi.org/
ID  - ref1
ER  -