TY  - JOUR
PY  - 2002//
TI  - [Fatal calcium polysulfide overdose presenting corrosive chemical injury of esophagus and sulf-hemoglobinemia]
JO  - Japanese journal of toxicology
A1  - Kiyota, Kazuya
A1  - Suzuki, Tsuneo
A1  - Adachi, Takuya
A1  - Nonaka, Akiko
A1  - Nishigawa, Yukihiro
A1  - Hamabe, Yuuichi
SP  - 171
EP  - 176
VL  - 15
IS  - 2
N2  - A-79-year-old woman ingested a cup of unknown violet agricultural solution intentionally. She was vomiting and smelt of sulfur. Arterial blood gas showed metabolic acidosis and marked cyanosis regardless of relatively high PaO2, caused by sulfhemoglobinemia. A nasogastric tube could not be inserted because of marked stenosis caused by endoscopically proven severe corrosive chemical injury (burn) of esophagus. Considering the smell and the clinical presentation, we concluded that the causative agent was calcium polysulfide or lime-sulphur solution, a common agricultural product used as a fungicide. Despite supportive therapy including infusion of NaNO2, the patient expired 4.5 hours after ingestion. Calcium polysulfide ingestions cause direct injury to the upper gastrointestinal tract, and react with gastric HCl producing poisonous H2S gas, which interferes cytochrome oxidase activity, developing tissue hypoxia, shock, and metabolic acidosis. Sulfhemoglobin is also produced causing severe cyanosis.<p /> <p>Language: ja</p>
LA  - ja
SN  - 0914-3777
UR  - http://dx.doi.org/
ID  - ref1
ER  -