TY  - JOUR
PY  - 2002//
TI  - Neurokinin-1 receptors are decreased in major depressive disorder
JO  - Neuroreport
A1  - Stockmeier, Craig A.
A1  - Shi, Xiaochun
A1  - Konick, Lisa
A1  - Overholser, James C.
A1  - Jurjus, George
A1  - Meltzer, Herbert Y.
A1  - Friedman, Lee
A1  - Blier, Pierre
A1  - Rajkowska, Grazyna
SP  - 1223
EP  - 1227
VL  - 13
IS  - 9
N2  - Treatment with an antagonist at the neurokinin-1 (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [125I]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n = 12, six females) and psychiatrically normal subjects (n = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.<p /> <p>Language: en</p>
LA  - en
SN  - 0959-4965
UR  - http://dx.doi.org/10.1097/00001756-200207020-00031
ID  - ref1
ER  -