TY  - JOUR
PY  - 2003//
TI  - An autopsy case of combined drug intoxication involving verapamil, metoprolol and digoxin
JO  - Forensic science international
A1  - Kinoshita, Hiroshi
A1  - Taniguchi, Tadaaki
A1  - Nishiguchi, Minori
A1  - Ouchi, Harumi
A1  - Minami, Takako
A1  - Utsumi, Takao
A1  - Motomura, Hiroyuki
A1  - Tsuda, Toyohiko
A1  - Ohta, Takehiko
A1  - Aoki, Shigeru
A1  - Komeda, Motoo
A1  - Kamamoto, Tetsuji
A1  - Kubota, Akira
A1  - Fuke, Chiaki
A1  - Arao, Tomonori
A1  - Miyazaki, Tetsuji
A1  - Hishida, Shigeru
SP  - 107
EP  - 112
VL  - 133
IS  - 1-2
N2  - We present here a fatal poisoning case involving verapamil, metoprolol and digoxin. A 39-year-old male was found dead in his room, and a lot of empty packets of prescribed drugs were found near the corpse. The blood concentrations of verapamil, metoprolol and digoxin were 9.2 microg/ml, 3.6 microg/ml and 3.2 ng/ml, respectively. The cause of death was given as cardiac failure, hypotension and bradycardia due to a mixed drug overdose of verapamil, metoprolol and digoxin, based on the results of the autopsy and toxicological examination. We speculate that the toxicity of verapamil is potentiated by drug interaction with metoprolol and digoxin.<p /> <p>Language: en</p>
LA  - en
SN  - 0379-0738
UR  - http://dx.doi.org/10.1016/s0379-0738(03)00056-2
ID  - ref1
ER  -