TY - JOUR PY - 2003// TI - The Heart Protection Study: high-risk patients benefit from statins, regardless of LDL-C level JO - Cleveland Clinic journal of medicine A1 - Gurm, Hitinder S. A1 - Hoogwerf, Byron SP - 991 EP - 997 VL - 70 IS - 11 N2 - The landmark Heart Protection Study (Lancet 2002; 360:7-22) found benefit in treating subjects at high risk of a coronary event with simvastatin 40 mg daily, regardless of baseline low-density lipoprotein cholesterol level and in all subgroups, including women and the elderly. The study found no benefit of simvastatin therapy in preventing noncardiac events (eg, dementia, osteoporotic fractures), and no negative effects, such as an increase in cancer, respiratory disease, or suicide.

Language: en

LA - en SN - 0891-1150 UR - http://dx.doi.org/10.3949/ccjm.70.11.991 ID - ref1 ER -