TY  - JOUR
PY  - 2004//
TI  - Acute oxcarbazepine and atomoxetine overdose with quetiapine
JO  - Veterinary and human toxicology
A1  - Barker, Michael J.
A1  - Benitez, John G.
A1  - Ternullo, Sharon
A1  - Juhl, Gregory A.
SP  - 130
EP  - 132
VL  - 46
IS  - 3
N2  - We present a case of acute oxcarbazepine and atomoxetine overdose combined with excess quetiapine in a 19-y-old male. The patient ingested approximately 36 g oxcarbazepine (514 mg/kg), 1.2 g atomoxetine (17 mg/kg), and 9 mg Quetiapine (128 mg/kg). Central nervous system (CNS) depression with initial unresponsiveness developed within 1 h of ingestion, necessitating intubation for airway protection. Despite aggressive therapy with whole bowel irrigation and charcoal administration, the patient's somnolence persisted for 4 d, punctuated by occasional violent outbursts. Prolonged QTc was noted initially, but normalized within 4 d. This case suggests that acute overdose of oxcarbazepine and atomoxetine combined with quetiapine is associated with rapid and prolonged CNS depression.<p /> <p>Language: en</p>
LA  - en
SN  - 0145-6296
UR  - http://dx.doi.org/
ID  - ref1
ER  -