TY  - JOUR
PY  - 2004//
TI  - [Deep lactic acidosis after valproate self-poisoning]
JO  - Annales Francaises d'Anesthesie et de Reanimation
A1  - Blayac, D.
A1  - Roch, A.
A1  - Michelet, P.
A1  - De Francheschi, E.
A1  - Auffray, J.-p.
SP  - 1007
EP  - 1010
VL  - 23
IS  - 10
N2  - A sixty-year-old woman was admitted in the ICU after Depamide (Valpromide) self-poisoning (430 mg/kg). Four hours after the ingestion, the patient presented coma (Glagow coma score of 3) with bilateral mydriasis requiring tracheal intubation and mechanical ventilation, hypotension requiring epinephrine infusion (0.9 microg/kg per minute), acidosis and hyperlactatemia (29.7 mmol/l at 12 hours) without any kidney or liver failure. The maximal serum valproic acid concentration measured was 342 mg/l after twelve hours (therapeutic rate: 35-85 mg/l). A continuous infusion of sodium bicarbonate was associated with continuous venovenous haemodiafiltration. Progressive haemodynamic improvement and neurologic recovery leaded to extubation at 36 hours.<p /> <p>Language: fr</p>
LA  - fr
SN  - 0750-7658
UR  - http://dx.doi.org/10.1016/j.annfar.2004.07.006
ID  - ref1
ER  -