TY  - JOUR
PY  - 2004//
TI  - Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric mania
JO  - British journal of psychiatry
A1  - Baker, Robert W.
A1  - Brown, Eileen
A1  - Akiskal, Hagop S.
A1  - Calabrese, Joseph R.
A1  - Ketter, Terence A.
A1  - Schuh, Leslie M.
A1  - Trzepacz, Paula T.
A1  - Watkin, John G.
A1  - Tohen, Mauricio
SP  - 472
EP  - 478
VL  - 185
IS  - 
N2  - BACKGROUND: Few controlled studies examine the treatment of depressive features in mania.  AIMS: To evaluate the efficacy of olanzapine, in combination with lithium or valproate, for treating depressive symptoms associated with mania.  METHOD: Secondary analysis of a 6-week, double-blind, randomised study of olanzapine (5-20 mg/day) or placebo combined with ongoing valproate or lithium open treatment for 344 patients in mixed or manic episodes. This analysis focused on a dysphoric subgroup with baseline Hamilton Rating Scale for Depression (HRSD) total scores of 20 or over contrasted with non-dysphoric patients.  RESULTS: In the dysphoric subgroup (n=85) mean HRSD total score improvement was significantly greater in olanzapine co-therapy patients than in those receiving placebo plus lithium or valproate (P<0.001). Substantial contributors to this superiority included the HRSD Maier sub-scale (P=0.013) and the suicide item (P=0.001). Total Young Mania Rating Scale improvement was also superior with olanzapine co-therapy.  CONCLUSIONS: In patients with acute dysphoric mania, addition of olanzapine to ongoing lithium or valproate monotherapy significantly improved depressive symptom, mania and suicidality ratings.<p /> <p>Language: en</p>
LA  - en
SN  - 0007-1250
UR  - http://dx.doi.org/10.1192/bjp.185.6.472
ID  - ref1
ER  -