TY  - JOUR
PY  - 2004//
TI  - High-dose exposure to valsartan with suicidal intention
JO  - International journal of clinical pharmacology and therapeutics
A1  - Kumbasar, B.
A1  - Atlibatur Akbas, F.
A1  - Serez, K.
A1  - Ger, E.
A1  - Uzunoglu, S.
A1  - Ergen, K.
A1  - Ayer, M.
SP  - 328
EP  - 329
VL  - 42
IS  - 6
N2  - Valsartan is a strong angiotensin receptor inhibitor specific for the angiotensin I receptor, which has been proven safe and well-tolerated in clinical trials. We were able to confirm its safety and tolerability in a case of high-dose exposure to valsartan with suicidal intention. A 25-year-old, fully conscious, female patient was brought to our hospital by relatives on July 24, 2001, at 9:15 p.m. following intake of a high dose of valsartan. It was established that she had taken 28 Diovan 80 mg tablets (2.24 g) 5 hours before admission to the hospital. Her clinical condition at the time of admission was good and did not deteriorate after admission. During the follow-up, her blood pressure never fell below 90/60 mmHg. The only complaint she had were painful muscle cramps which, with only supportive therapy, disappeared spontaneously over 2 days, and her blood pressure also returned to normal during this period. This report demonstrates the effect/side effect profile of valsartan when taken at a high dose, not achievable in a clinical trial.<p /> <p>Language: en</p>
LA  - en
SN  - 0946-1965
UR  - http://dx.doi.org/10.5414/cpp42328
ID  - ref1
ER  -