TY  - JOUR
PY  - 2004//
TI  - L-histidine stimulates sympathetic nerve activity to brown adipose tissue in rats
JO  - Neuroscience letters
A1  - Yasuda, Tohru
A1  - Masaki, Takayuki
A1  - Chiba, Seiichi
A1  - Kakuma, Tetsuya
A1  - Sakata, Toshiie
A1  - Yoshimatsu, Hironobu
SP  - 71
EP  - 74
VL  - 362
IS  - 2
N2  - Hypothalamic neuronal histamine is involved in the central regulation of energy expenditure through the activation of sympathetic nerves innervating brown adipose tissue (BAT). The present study examined the effect of L-histidine, a precursor of neuronal histamine, on BAT sympathetic nerve activity in rats. Infusion of histamine at a dose of 1 nmol/rat into the third cerebroventricle significantly increased BAT sympathetic nerve activity as compared with the effect of phosphate buffered saline (P < 0.05). Intraperitoneal (i.p.) injection of L-histidine (0.3 mmol/rat) also significantly increased BAT sympathetic nerve activity as compared with the effect of PBS (P < 0.05). Pretreatment with an i.p. bolus injection of 224 micromol/kg alpha-fluoromethylhistidine, a suicide inhibitor of the histamine synthesizing enzyme histidine decarboxylase, blocked the stimulatory effect of l-histidine on BAT sympathetic nerve activity. These results indicate that L-histidine regulates BAT sympathetic nerve activity through its conversion into neuronal histamine in the hypothalamus.<p /> <p>Language: en</p>
LA  - en
SN  - 0304-3940
UR  - http://dx.doi.org/10.1016/j.neulet.2003.10.052
ID  - ref1
ER  -