TY  - JOUR
PY  - 2006//
TI  - Determination of chlorhexidine (CHD) and nonylphenolethoxylates (NPEOn) using LC-ESI-MS method and application to hemolyzed blood
JO  - Journal of chromatography B: analytical technologies in the biomedical and life sciences
A1  - Usui, Kiyotaka
A1  - Hishinuma, Takanori
A1  - Yamaguchi, Hiroaki
A1  - Tachiiri, Naoki
A1  - Goto, Junichi
SP  - 105
EP  - 109
VL  - 831
IS  - 1-2
N2  - Rapid and reliable methods for identification of chlorhexidine (CHD) and nonylphenolethoxylates (NPEOn) in antiseptic and hemolyzed blood using electrospray ionization mass spectrometry (ESI-MS) were developed. Fragmental analysis provides accurate evidence for the presence of CHD in the samples. For the determination of CHD in hemolyzed blood, the method was also developed using LC-ESI-MS. Linearity of calibration curve was obtained over the concentration range of 0.1-11 microg/mL with residuals from -4.3 to 6.7%. We applied the methods to the case of suicidal injection of antiseptic and successfully detected CHD and NPEOn from hemolyzed blood. The CHD concentration was 352 microg/mL.<p /> <p>Language: en</p>
LA  - en
SN  - 1570-0232
UR  - http://dx.doi.org/10.1016/j.jchromb.2005.11.051
ID  - ref1
ER  -