TY  - JOUR
PY  - 2006//
TI  - [Alcohol abuse case of severe liver dysfunction induced by acetaminophen poisoning which was diagnosed as non-hepatic toxicity on admission]
JO  - Japanese journal of toxicology
A1  - Inoue, Shigeaki
A1  - Yamamoto, Isotoshi
A1  - Akieda, Kazuki
A1  - Sekiguchi, Hiroshi
A1  - Otuka, Hiroyuki
A1  - Morita, Seiji
A1  - Nakagawa, Yoshihide
A1  - Inokuchi, Sadaki
SP  - 265
EP  - 271
VL  - 19
IS  - 3
N2  - A 41-year-old female attempted suicide by taking 7.8g acetaminophen and was transferred to our hospital four hours after ingestion. The patient was diagnosed as non-hepatic toxicity (below the line set by the Rumack Matthew nomogram). Laboratory data showed an elevation in serum liver enzymes and coagulation defects at 3 days after ingestion, therefore, the patient was treated with plasma exchange and an oral administration of N-acetylcysteine (NAC). The elevation of liver enzymes was maximal at 4 days after ingestion, and the laboratory data became normalized at approximately 9 days after ingestion. In this case, habitual alcohol intake may have exacerbated the severe liver injury. We should consider an exacerbation of hepatotoxicity and administer NAC in any case having a history of habitual alcohol intake, even if the case was diagnosed as non-hepatic toxicity by the nomogram.<p /> <p>Language: ja</p>
LA  - ja
SN  - 0914-3777
UR  - http://dx.doi.org/
ID  - ref1
ER  -