TY  - JOUR
PY  - 2006//
TI  - Neither DMPS nor DMSA is effective in quantitative elimination of elemental mercury after intentional IV injection
JO  - Clinical toxicology (Philadelphia, Pa.)
A1  - Eyer, Florian
A1  - Felgenhauer, Norbert
A1  - Pfab, Rudolf
A1  - Drasch, Gustav
A1  - Zilker, Thomas
SP  - 395
EP  - 397
VL  - 44
IS  - 4
N2  - BACKGROUND: Intravenous injection of elemental mercury (Hg) is rare and considered relatively harmless. Treatment recommendations vary and the effectiveness of chelation therapy is controversial.  CASE REPORT: A 27-year-old man intravenously injected 1.5 mL of elemental Hg. Within 12 hours he became febrile, tachycardic and dyspneic. Physical examination was unremarkable. X-rays showed scattered radiodense deposits in the lung, heart, intestinal wall, liver and kidney. The serum Hg level on admission was 172 microg/L and peaked on day 6 at 274 microg/L. Cumulative renal elimination during a five day oral treatment period with 2,3-dimercaptopropane-1-sulfonate (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) was 8 mg and 3 mg, respectively.  CONCLUSION: Although urinary excretion could be enhanced during chelation therapy, Hg deposits in organs resulted in negligible elimination of mercury compared to the exposed dose.<p /> <p>Language: en</p>
LA  - en
SN  - 1556-3650
UR  - http://dx.doi.org/10.1080/15563650600671795
ID  - ref1
ER  -