TY  - JOUR
PY  - 2006//
TI  - Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine
JO  - Organic and biomolecular chemistry
A1  - Alexeev, Dmitriy
A1  - Baxter, Robert L.
A1  - Campopiano, Dominic J.
A1  - Kerbarh, Olivier
A1  - Sawyer, Lindsay
A1  - Tomczyk, Nicholas
A1  - Watt, Rory
A1  - Webster, Scott P.
SP  - 1209
EP  - 1212
VL  - 4
IS  - 7
N2  - The irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct.<p /> <p>Language: en</p>
LA  - en
SN  - 1477-0520
UR  - http://dx.doi.org/10.1039/b517922j
ID  - ref1
ER  -