TY  - JOUR
PY  - 2006//
TI  - [The serotonin syndrome. Fatal course of intoxication with citalopram and moclobemide]
JO  - Anaesthesist, Der
A1  - Cassens, S.
A1  - Nickel, E. A.
A1  - Quintel, M.
A1  - Neumann, P.
SP  - 1189
EP  - 1196
VL  - 55
IS  - 11
N2  - The serotonin syndrome is caused by a drug-induced increase of the intrasynaptic serotonin concentration. Milder forms of the syndrome may be difficult to diagnose because of the variability of symptoms. Severe forms often rapidly turn into a life-threatening situation, therefore the serotonin syndrome may be a challenge for physicians. We describe the pathophysiology and therapeutic options of the serotonin syndrome and report about a 42-year-old female patient who ingested large amounts of moclobemide, a monoamine oxidase inhibitor, and citalopram, a selective serotonin reuptake inhibitor, for attempted suicide. Within a few hours the patient developed a lethal serotonin syndrome although ICU therapy was initiated immediately.<p /> <p>Language: de</p>
LA  - de
SN  - 0003-2417
UR  - http://dx.doi.org/10.1007/s00101-006-1089-1
ID  - ref1
ER  -