TY  - JOUR
PY  - 2008//
TI  - Acute pulmonary edema associated with naphazoline ingestion
JO  - Clinical toxicology (Philadelphia, Pa.)
A1  - Fukushima, Hidetada
A1  - Norimoto, Kazunobu
A1  - Seki, Tadahiko
A1  - Nishiguchi, Takashi
A1  - Nakamura, Tatsuya
A1  - Konobu, Toshifumi
A1  - Nishio, Kenji
A1  - Okuchi, Kazuo
SP  - 254
EP  - 256
VL  - 46
IS  - 3
N2  - In published reports of naphazoline ingestion, clinical effects are hypertension, bradycardia, pallor, diaphoresis, and respiratory distress. We report three cases of acute pulmonary edema after the intentional ingestion of naphazoline-containing antiseptic first aid liquid. These cases presented with altered mental status, hypertension, bradycardia, and diaphoresis. Chest x-ray on admission revealed acute pulmonary edema. Two cases required mechanical ventilation. All of these clinical effects resolved within 24 hours and the patients were discharged with no sequelae. Since naphazoline stimulates the peripheral alpha-2 adrenergic receptor, we speculate that intense vasoconstriction may have elevated cardiac afterload and left atrial-ventricular blood volume and caused acute pulmonary edema.<p /> <p>Language: en</p>
LA  - en
SN  - 1556-3650
UR  - http://dx.doi.org/10.1080/15563650701438441
ID  - ref1
ER  -