TY  - JOUR
PY  - 2008//
TI  - Metabolic acidosis in prometryn (triazine herbicide) self-poisoning
JO  - Clinical toxicology (Philadelphia, Pa.)
A1  - Brvar, Miran
A1  - Okrajsek, Renata
A1  - Kosmina, Polona
A1  - Staric, Feliks
A1  - Kaps, Rafael
A1  - Kozelj, Gordana
A1  - Bunc, Matjaz
SP  - 270
EP  - 273
VL  - 46
IS  - 3
N2  - INTRODUCTION: Prometryn is a triazine herbicide, which is one of the most extensively used groups of herbicides. The mechanism of acute triazine herbicide toxicity in humans is not known. We report a first case of acute prometryn poisoning.  CASE REPORT: A 62-year-old male ingested 50 g of prometryn and ethanol in a suicide attempt. On arrival two hours after ingestion, he was somnolent and vomited. Seven hours after ingestion laboratory tests showed metabolic acidosis with a calculated anion gap of 47.5 mmol/L and lactate of 23.4 mmol/L. Gas chromatography/mass spectrometry revealed serum prometryn concentrations of 48.1 mg/L. Hemodialysis corrected metabolic acidosis, but the serum prometryn concentration increased to 67.7 mg/L. The lactate level after hemodialysis was 11.7 mmol/L and returned within normal limits 47 hours after ingestion. The patient was discharged without any sequelae after psychiatric evaluation.  CONCLUSION: In high anion gap metabolic acidosis we should consider poisoning with prometryn and other triazine herbicides. Hemodialysis corrects metabolic derangements, but it does not lower serum prometryn concentration.<p /> <p>Language: en</p>
LA  - en
SN  - 1556-3650
UR  - http://dx.doi.org/10.1080/15563650701665126
ID  - ref1
ER  -