TY  - JOUR
PY  - 2008//
TI  - Intoxications due to ingestion of gamma-butyrolactone: organ distribution of gamma-hydroxybutyric acid and gamma-butyrolactone
JO  - Therapeutic drug monitoring
A1  - Lenz, Daniel
A1  - Rothschild, Markus A.
A1  - Kröner, Lars
SP  - 755
EP  - 761
VL  - 30
IS  - 6
N2  - In Europe, the misuse of gamma-hydroxybutyric acid (GHB) and its analogues has increased within the recent years. Here, 2 fatalities and 1 nonfatal intoxication resulting from ingestion of gamma-butyrolactone (GBL), a precursor of GHB, are presented. GHB was quantified involving the conversion to GBL by application of a gas chromatography-mass spectrometry (GC/MS) method. Besides quantitation of GHB equivalents ("total GBL"), all specimens of case 1 were analyzed for the metabolic precursor GBL itself (absolute GBL). The cause of death in each case was attributed to GHB intoxication; the manner of death was suicide in the first case and accidental in the second one. Another yet nonfatal GHB intoxication was reported by an emergency department concerning a 36-year-old woman who was hospitalized due to her comatose state and loss of adverse effects reflexes. Here nail polish remover pads were used as source for GBL.<p /> <p>Language: en</p>
LA  - en
SN  - 0163-4356
UR  - http://dx.doi.org/10.1097/FTD.0b013e3181898c2e
ID  - ref1
ER  -