TY  - JOUR
PY  - 2009//
TI  - Altered glucose tolerance in women with deliberate self-harm
JO  - Psychoneuroendocrinology
A1  - Westling, Sofie
A1  - Ahrén, Bo
A1  - Sunnqvist, Charlotta
A1  - Träskman-Bendz, Lil
SP  - 878
EP  - 883
VL  - 34
IS  - 6
N2  - Disturbances in glucose metabolism are of importance for violent behaviour in men, but studies in women are lacking. We used the 5h-oral glucose tolerance test (OGTT) in this study of 17 female psychiatric patients, selected for violent behaviour directed against themselves (deliberate self-harm) and 17 healthy controls matched for age and BMI. Following OGTT, patients had higher glucose levels at 30 min (p=0.007) and increased glucagon area under the curve (p=0.011). Since a co-morbid eating disorder might affect results, we as a post-hoc analysis subgrouped the patients and found that the increased glucagon levels only were present in patients with an eating disorder. In contrast, those without an eating disorder showed a significantly lower p-glucose nadir (p=0.015) and unaltered glucagon levels compared to controls. There were no significant differences in insulin and C-peptide levels between patients and controls. We conclude that deliberate self-harm in women may be associated with alterations in carbohydrate metabolism in certain groups. Eating disorder is a confounding factor.<p /> <p>Language: en</p>
LA  - en
SN  - 0306-4530
UR  - http://dx.doi.org/10.1016/j.psyneuen.2008.12.015
ID  - ref1
ER  -