TY  - JOUR
PY  - 2011//
TI  - Admixture analysis of age at onset in bipolar disorder
JO  - Psychiatry research
A1  - Tozzi, Federica
A1  - Manchia, Mirko
A1  - Galwey, Nicholas W.
A1  - Severino, Giovanni
A1  - Del Zompo, Maria
A1  - Day, Richard
A1  - Matthews, Keith
A1  - Strauss, John
A1  - Kennedy, James L.
A1  - McGuffin, Peter
A1  - Vincent, John B.
A1  - Farmer, Anne
A1  - Muglia, Pierandrea
SP  - 27
EP  - 32
VL  - 185
IS  - 1-2
N2  - The aim of this study was to identify whether age at onset (AAO) identifies Bipolar Disorder (BD) subtypes, and to test whether the subgroups were confirmed by different clinical profiles. Admixture analysis was applied to determine a model that best fit the observed distribution of AAO in 964 BD patients. Three distributions of AAO were identified, and age means were 16.1 (S.D. 4.2), 25.4 (S.D. 2.5) and 32.2 (S.D. 9.5) years. A significant increased rate of suicide attempts, Bipolar I (BD I) caseness, and depressive onset was observed in the early-onset group when compared to those with later-onset by means of χ². <br><br>FINDINGS from extant studies and our results are remarkably consistent in showing that BD can be subdivided into three groups based on AAO distributions, and that early-onset is associated with higher rates of suicide attempts.<p /> <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2009.11.025
ID  - ref1
ER  -