TY  - JOUR
PY  - 2011//
TI  - Methadone-induced toxic leukoencephalopathy: diagnosis and follow-up by magnetic resonance imaging including diffusion-weighted imaging and apparent diffusion coefficient maps
JO  - Journal of neuroimaging
A1  - Cerase, Alfonso
A1  - Leonini, Sara
A1  - Bellini, Matteo
A1  - Chianese, Giuseppe
A1  - Venturi, Carlo
SP  - 283
EP  - 286
VL  - 21
IS  - 3
N2  - BACKGROUND AND PURPOSE: Effects of methadone misuse have been rarely described. The purpose of this case report is to increase the knowledge of methadone-related leukoencephalopathy.  METHODS: We report the long-term follow-up by brain magnetic resonance imaging including isotropic diffusion-weighted imaging and mean apparent diffusion coefficient values of a 49-year-old patient who attempted suicide by intravenous methadone.  RESULTS AND CONCLUSIONS: Lesion pattern included subtle cerebellar involvement, mainly reversible extensive bilateral and symmetric brain involvement, cystic degeneration in the periventricular regions, sparing of corpus callosum and subcortical U-fibers, development of diffuse brain atrophy, and clear-cut clinical improvement.<p /> <p>Language: en</p>
LA  - en
SN  - 1051-2284
UR  - http://dx.doi.org/10.1111/j.1552-6569.2010.00530.x
ID  - ref1
ER  -