TY  - JOUR
PY  - 2010//
TI  - Plasma level of malondialdehyde in the cases of acute paraquat intoxication
JO  - Clinical toxicology (Philadelphia, Pa.)
A1  - Gil, Hyo-Wook
A1  - Seok, Su-Jin
A1  - Jeong, Du-Shin
A1  - Yang, Jong-Oh
A1  - Lee, Eun-Young
A1  - Hong, Sae-Yong
SP  - 149
EP  - 152
VL  - 48
IS  - 2
N2  - BACKGROUND, MATERIAL, AND METHODS: To assess plasma malondialdehyde (MDA) level as a clinical marker in acute paraquat (PQ) intoxication, we sequentially investigated 74 patients (40 males and 34 females, aged 49.9 +/- 16.2 years), all of whom ingested PQ as a means of suicide from July to December 2008.  RESULTS: The baseline level of MDA (10.8 +/- 3.5 microM) had no correlation with plasma PQ levels of 22.1 +/- 48.7 microg/mL (median: 1.9, range <0.01-228.5) or with volume of PQ ingested. However, the following parameters were significantly different between survivors and nonsurvivors: the amount of PQ ingestion, plasma PQ levels, basal MDA levels, WBC, hemoglobin, hematocrit, platelet counts, albumin, BUN, creatinine, potassium, amylase, and arterial blood gas analysis (pH, pCO(2), HCO(-)(3)).The nonsurvivors' baseline MDA (11.4 +/- 3.8 vs. 9.8 +/- 2.8, p = 0.040) was higher than the survivors. However, the baseline level was not a predictor of mortality in the univariate and the multivariate binary logistic analyses. Among the patients whose MDA levels were measured sequentially, 58.3% of the patients (35 out of 60) showed fluctuating MDA levels, 25% (n = 15) showed steady decreases, with only 16.6% (n = 10) showing steady increases in MDA levels during the observation period. These findings imply the presence of active MDA metabolism and/or that the half-life of MDA is very short in the human body.  CONCLUSION: Both cross-sectional and sequential measurements of plasma MDA do not provide reliable information on outcome in patients with acute PQ intoxication.<p /> <p>Language: en</p>
LA  - en
SN  - 1556-3650
UR  - http://dx.doi.org/10.3109/15563650903468803
ID  - ref1
ER  -