TY  - JOUR
PY  - 2010//
TI  - Suicidality and brain volumes in pediatric epilepsy
JO  - Epilepsy and behavior
A1  - Caplan, Rochelle
A1  - Siddarth, Prabha
A1  - Levitt, Jennifer
A1  - Gurbani, Suresh
A1  - Shields, W. Donald
A1  - Sankar, Raman
SP  - 286
EP  - 290
VL  - 18
IS  - 3
N2  - This study examined the relationship between suicidal ideation and frontotemporal volumes, particularly orbital frontal gyrus volume, in 51 subjects with epilepsy with a mean age of 9.8 (2.1) years. Structured psychiatric interviews of the children and parents provided information on suicidal behavior and DSM-IV diagnoses. Tissue of 1.5-T MRI scans was segmented, and total brain, frontal lobe, frontal parcellations, and temporal lobe volumes were computed. The 11 subjects with epilepsy with suicidal ideation had significantly smaller right orbital frontal gyrus white matter volumes and larger left temporal lobe gray matter volumes than the 40 children without suicidal thoughts. Given the role of the orbital frontal gyrus in both emotional regulation and epilepsy, these findings highlight the biological underpinnings of suicidal ideation in pediatric epilepsy.<p /> <p>Language: en</p>
LA  - en
SN  - 1525-5050
UR  - http://dx.doi.org/10.1016/j.yebeh.2010.04.018
ID  - ref1
ER  -