TY  - JOUR
PY  - 2010//
TI  - Two-year outcome of vagus nerve stimulation in treatment-resistant depression
JO  - Journal of clinical psychopharmacology
A1  - Bajbouj, Malek
A1  - Merkl, Angela
A1  - Schlaepfer, Thomas E.
A1  - Frick, Caroline
A1  - Zobel, Astrid
A1  - Maier, Wolfgang
A1  - O'Keane, Veronica
A1  - Corcoran, Ciaran
A1  - Adolfsson, Rolf
A1  - Trimble, Michael
A1  - Rau, Harald
A1  - Hoff, Hans-Joachim
A1  - Padberg, Frank
A1  - Müller-Siecheneder, Florian
A1  - Audenaert, Kurt
A1  - Van den Abbeele, Dirk
A1  - Matthews, Keith
A1  - Christmas, David
A1  - Eljamel, Sam
A1  - Heuser, Isabella
SP  - 273
EP  - 281
VL  - 30
IS  - 3
N2  - One of the major goals of antidepressant treatment is a sustained response and remission of depressive symptoms. Some of the previous studies of vagus nerve stimulation (VNS) have suggested antidepressant effects. Our naturalistic study assessed the efficacy and the safety of VNS in 74 European patients with therapy-resistant major depressive disorder. Psychometric measures were obtained after 3, 12, and 24 months of VNS. Mixed-model repeated-measures analysis of variance revealed a significant reduction (P < or = 0.05) at all the 3 time points in the 28-item Hamilton Rating Scale for Depression (HRSD28) score, the primary outcome measure. After 2 years, 53.1% (26/49) of the patients fulfilled the response criteria (> or =50% reduction in the HRSD28 scores from baseline) and 38.9% (19/49) fulfilled the remission criteria (HRSD28 scores < or = 10). The proportion of patients who fulfilled the remission criteria remained constant as the duration of VNS treatment increased. Voice alteration, cough, and pain were the most frequently reported adverse effects. Two patients committed suicide during the study; no other deaths were reported. No statistically significant differences were seen in the number of concomitant antidepressant medications. The results of this 2-year open-label trial suggest a clinical response and a comparatively benign adverse effect profile among patients with treatment-resistant depression.<p /> <p>Language: en</p>
LA  - en
SN  - 0271-0749
UR  - http://dx.doi.org/10.1097/JCP.0b013e3181db8831
ID  - ref1
ER  -