TY  - JOUR
PY  - 2011//
TI  - Behavioral effects of congenital ventromedial prefrontal cortex malformation
JO  - BMC neurology
A1  - Boes, Aaron D.
A1  - Grafft, Amanda Hornaday
A1  - Joshi, Charuta
A1  - Chuang, Nathaniel A.
A1  - Nopoulos, Peg
A1  - Anderson, Steven W.
SP  - e151
EP  - e151
VL  - 11
IS  - 
N2  - BACKGROUND: A detailed behavioral profile associated with focal congenital malformation of the ventromedial prefrontal cortex (vmPFC) has not been reported previously. Here we describe a 14 year-old boy, B.W., with neurological and psychiatric sequelae stemming from focal cortical malformation of the left vmPFC.  CASE PRESENTATION: B.W.'s behavior has been characterized through extensive review Patience of clinical and personal records along with behavioral and neuropsychological testing. A central feature of the behavioral profile is severe antisocial behavior. He is aggressive, manipulative, and callous; features consistent with psychopathy. Other problems include: egocentricity, impulsivity, hyperactivity, lack of empathy, lack of respect for authority, impaired moral judgment, an inability to plan ahead, and poor frustration tolerance.  CONCLUSIONS: The vmPFC has a profound contribution to the development of human prosocial behavior. B.W. demonstrates how a congenital lesion to this cortical region severely disrupts this process.<p /> <p>Language: en</p>
LA  - en
SN  - 1471-2377
UR  - http://dx.doi.org/10.1186/1471-2377-11-151
ID  - ref1
ER  -